Affiliation:
1. Kavli Institute for Systems Neuroscience and Centre for Neural Computation, Norwegian University of Science and Technology, Olav Kyrres gate 9, Norwegian Brain Centre, 7491 Trondheim, Norway.
Abstract
The lights go on in order
Grid cells and place cells in the brain function as part of a circuit that helps us figure out where we are in our physical world. Donato
et al.
examined how that circuit develops in the brains of mice. Expression patterns of doublecortin and parvalbumin revealed that neurons in the circuit mature in the order in which information flows. Maturation of each piece of the circuit depends on excitatory neuronal activity from the preceding portion. Stellate cells, in contrast, follow an endogenous maturation program. The stellate cells are responsible for initiating the circuit's developmental progression.
Science
, this issue p.
eaai8178
Funder
European Research Council
Kavli Foundation
Egil and Pauline Braathen and Fred Kavli Centre for Cortical Microcircuits
Louis-Jeantet Prize for Medicine
Centre of Excellence Scheme
National Infrastructure Scheme of the Research Council of Norway
European Molecular Biology Organization
Publisher
American Association for the Advancement of Science (AAAS)
Cited by
112 articles.
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