The Human K-Complex Represents an Isolated Cortical Down-State-Reference-Cited by-同舟云学术

The Human K-Complex Represents an Isolated Cortical Down-State

Published:2009-05-22 Issue:5930 Volume:324 Page:1084-1087
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Cash Sydney S.¹,Halgren Eric²,Dehghani Nima²,Rossetti Andrea O.³,Thesen Thomas⁴,Wang ChunMao⁴,Devinsky Orrin⁴,Kuzniecky Ruben⁴,Doyle Werner⁴,Madsen Joseph R.⁵,Bromfield Edward³,Erőss Loránd⁶,Halász Péter⁷⁸,Karmos George⁹⁸,Csercsa Richárd⁹,Wittner Lucia⁶⁹,Ulbert István⁶⁹⁸

Affiliation:

1. Department of Neurology, Epilepsy Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.

2. Departments of Radiology, Neurosciences, and Psychiatry, University of California at San Diego, San Diego, CA 92093, USA.

3. Brigham and Women’s Hospital, Boston, MA 02115, USA.

4. Comprehensive Epilepsy Center, New York University School of Medicine, New York, NY 10016, USA.

5. The Children’s Hospital, Boston, MA 02115, USA.

6. National Institute of Neurosurgery, H-1145 Budapest, Hungary.

7. National Institute of Psychiatry and Neurology, Epilepsy Center, H-1145 Budapest, Hungary.

8. Péter Pázmány Catholic University, Department of Information Technology, H-1083 Budapest, Hungary.

9. Institute for Psychology, Hungarian Academy of Sciences, H-1394 Budapest, Hungary.

Abstract

Down But Not Out The K-complex, a defining characteristic of slow wave sleep, is the largest spontaneously occurring component of the healthy human electroencephalogram (EEG) but little is known about its physiological characteristics in the human cortex. Cash et al. (p. 1084 ) investigated the intracortical origin of K-complexes in humans undergoing surgery for epileptic seizures. In simultaneous subdural EEG and intracortical multisite microelectrode recordings, K complexes represented cortical downstates reflecting a decrease in neural firing. These down-states are a fundamental mode of cortical operation that have been well studied in animals and may contribute to sleep preservation and memory consolidation.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference26 articles.

1. G. Buzsaki Rhythms of the Brain (Oxford Univ. Press Oxford 2006).

2. Loomis A. L., Harvey E. N., Hobart G., J. Neurophysiol. 13 (suppl.), 231 (1938).

3. The K-Complex: A 7-Decade History

4. K-complex, a reactive EEG graphoelement of NREM sleep: an old chap in a new garment

5. Cholinergic and noradrenergic modulation of the slow (approximately 0.3 Hz) oscillation in neocortical cells

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