Spatiotemporal expansion of primary progenitor zones in the developing human cerebellum-Reference-Cited by-同舟云学术

Spatiotemporal expansion of primary progenitor zones in the developing human cerebellum

Published:2019-10-25 Issue:6464 Volume:366 Page:454-460
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Haldipur Parthiv¹,Aldinger Kimberly A.¹,Bernardo Silvia²,Deng Mei³,Timms Andrew E.⁴,Overman Lynne M.⁵,Winter Conrad¹,Lisgo Steven N.⁵,Razavi ⁶,Silvestri Evelina⁷,Manganaro Lucia²,Adle-Biassette Homa⁸⁹,Guimiot Fabien¹⁰,Russo Rosa¹¹,Kidron Debora¹²,Hof Patrick R.¹³,Gerrelli Dianne¹⁴,Lindsay Susan J.⁵,Dobyns William B.¹³,Glass Ian A.¹³,Alexandre Paula¹⁴,Millen Kathleen J.¹³

Affiliation:

1. Center for Integrative Brain Research, Seattle Children’s Research Institute, Seattle, WA, USA.

2. Departments of Experimental Medicine and Radiological Sciences, Sapienza University of Rome, Rome, Italy.

3. Department of Pediatrics, University of Washington, Seattle, WA, USA.

4. Center for Developmental Biology and Regenerative Medicine, Seattle Children’s Research Institute, Seattle, WA, USA.

5. Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, UK.

6. Hôpital Necker-Enfants Malades, Assistance Publique Hôpitaux de Paris, Paris, France.

7. Surgical Pathology Unit, San Camillo Forlanini Hospital, Rome, Italy.

8. Department of Pathology, Hôpital Lariboisière, Assistance Publique Hôpitaux de Paris, Paris, France.

9. NeuroDiderot, INSERM, Université de Paris, Paris, France.

10. Hôpital Robert-Debré, INSERM UMR 1141, Paris, France.

11. Department of Pathology, University Medical Hospital, Salerno, Italy.

12. Department of Pathology, Meir Medical Center, Kfar Saba and Sackler School of Medicine, Tel Aviv University, Israel.

13. Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

14. University College London Great Ormond Street Institute of Child Health, London, UK.

Abstract

Close-up of human cerebellar development Early on, cerebellar development shares similarities across humans, nonhuman primates, and even mice. But differences emerge while development progresses, as cellular and molecular analyses by Haldipur et al. now reveal. The rhombic lip persists longer during cerebellar development in humans than in either the mouse or the macaque and generates a pool of neuroprogenitor cells. Similarly, the ventricular zone of the human cerebellum goes a step further than that of the mouse in developing an additional proliferative layer with outer radial glia cells. Transcriptome analysis revealed detailed similarities and differences between progenitor cells of the developing human cerebellum and neocortex. Science , this issue p. 454

Funder

National Institutes of Health

Burroughs Wellcome Fund

European Molecular Biology Organization

Company of Biologists

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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