Compartmentalized Control of Skin Immunity by Resident Commensals-Reference-Cited by-同舟云学术

Compartmentalized Control of Skin Immunity by Resident Commensals

Published:2012-08-31 Issue:6098 Volume:337 Page:1115-1119
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Naik Shruti¹²,Bouladoux Nicolas¹,Wilhelm Christoph¹,Molloy Michael J.¹,Salcedo Rosalba³⁴,Kastenmuller Wolfgang⁵,Deming Clayton⁶,Quinones Mariam⁷,Koo Lily⁸,Conlan Sean⁶,Spencer Sean¹²,Hall Jason A.⁹,Dzutsev Amiran³⁴,Kong Heidi¹⁰,Campbell Daniel J.¹¹¹²,Trinchieri Giorgio³,Segre Julia A.⁶,Belkaid Yasmine¹

Affiliation:

1. Mucosal Immunology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.

2. Immunology Graduate Group, University of Pennsylvania, Philadelphia, PA 19104, USA.

3. Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA.

4. SAIC-Frederick Inc., National Cancer Institute, Frederick, MD 21701, USA.

5. Lymphocyte Biology Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.

6. Genetics and Molecular Biology Branch, National Human Genome Research Institute, Bethesda, MD 20892, USA.

7. Bioinformatics and Computational Biosciences Branch, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.

8. Research Technology Branch, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.

9. Molecular Pathogenesis Program, Kimmel Center for Biology and Medicine, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA.

10. Dermatology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA.

11. Benaroya Research Institute, Seattle, WA 98101, USA.

12. Department of Immunology, University of Washington School of Medicine, Seattle, WA 98195, USA.

Abstract

Skin Specifics Much of the recent attention paid to the trillions of bacteria that colonize our bodies has been given to the bacteria that reside in the gut. Naik et al. (p. 1115 , published online 26 July) report that colonization of the skin with commensal bacteria is important for tuning effector T cell responses in the skin and for protective immunity against cutaneous infection with the parasite Leishmania major in mice. In contrast, selective depletion of the gut microbiota, which plays an important role in modulating immune responses in the gut, had no impact on T cell responses in the skin.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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