Extension of Life-Span by Loss of CHICO, a Drosophila Insulin Receptor Substrate Protein-Reference-Cited by-同舟云学术

Extension of Life-Span by Loss of CHICO, a Drosophila Insulin Receptor Substrate Protein

Published:2001-04-06 Issue:5514 Volume:292 Page:104-106
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Clancy David J.¹,Gems David¹,Harshman Lawrence G.²,Oldham Sean³,Stocker Hugo³,Hafen Ernst³,Leevers Sally J.⁴⁵,Partridge Linda¹

Affiliation:

1. Department of Biology, University College London, Wolfson House, 4 Stephenson Way, London NW1 2HE, UK.

2. School of Biological Sciences, University of Nebraska–Lincoln, Lincoln, NE 68588, USA.

3. Zoologisches Institut, Universität Zürich, Winterthurerstrasse 190, 8057 Zürich, Switzerland.

4. Ludwig Institute for Cancer Research, 91 Riding House Street, London W1W 7BS, UK.

5. Department of Biochemistry and Molecular Biology, University College London, Gower Street, London WC1E 6BT, UK.

Abstract

The Drosophila melanogaster gene chico encodes an insulin receptor substrate that functions in an insulin/insulin-like growth factor (IGF) signaling pathway. In the nematode Caenorhabditis elegans , insulin/IGF signaling regulates adult longevity. We found that mutation of chico extends fruit fly median life-span by up to 48% in homozygotes and 36% in heterozygotes. Extension of life-span was not a result of impaired oogenesis in chico females, nor was it consistently correlated with increased stress resistance. The dwarf phenotype of chico homozygotes was also unnecessary for extension of life-span. The role of insulin/IGF signaling in regulating animal aging is therefore evolutionarily conserved.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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