The Human Malaria Parasite Pfs47 Gene Mediates Evasion of the Mosquito Immune System-Reference-Cited by-同舟云学术

The Human Malaria Parasite Pfs47 Gene Mediates Evasion of the Mosquito Immune System

Published:2013-05-24 Issue:6135 Volume:340 Page:984-987
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Molina-Cruz Alvaro¹,Garver Lindsey S.¹,Alabaster Amy¹,Bangiolo Lois¹,Haile Ashley¹,Winikor Jared¹,Ortega Corrie¹,van Schaijk Ben C. L.²,Sauerwein Robert W.²,Taylor-Salmon Emma¹,Barillas-Mury Carolina¹

Affiliation:

1. Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20892, USA.

2. Department of Medical Microbiology, Radboud University Nijmegen Medical Center, 268, Post Office Box 9101, 6500 HB Nijmegen, Netherlands.

Abstract

Malaria Cloak and Dagger Mosquitoes have a complex immune system capable of effective antiparasite responses; however, malaria transmission is still highly efficient. Molina-Cruz et al. (p. 984 , published online 9 May; see the Perspective by Philip and Waters ) show that Plasmodium falciparum has a gene product, Pfs47 , that makes the parasite's ookinetes “invisible” to the mosquito immune system. Disruption of this mechanism could potentially be used to block malaria transmission.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference26 articles.

1. Inducible Peroxidases Mediate Nitration of Anopheles Midgut Cells Undergoing Apoptosis in Response to Plasmodium Invasion

2. Epithelial Nitration by a Peroxidase/NOX5 System Mediates Mosquito Antiplasmodial Immunity

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4. Caspar Controls Resistance to Plasmodium falciparum in Diverse Anopheline Species

5. Fine Pathogen Discrimination within the APL1 Gene Family Protects Anopheles gambiae against Human and Rodent Malaria Species

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