Enhancement of Zika virus pathogenesis by preexisting antiflavivirus immunity-Reference-Cited by-同舟云学术

Enhancement of Zika virus pathogenesis by preexisting antiflavivirus immunity

Published:2017-04-14 Issue:6334 Volume:356 Page:175-180
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Bardina Susana V.¹^ORCID,Bunduc Paul¹^ORCID,Tripathi Shashank¹²^ORCID,Duehr James¹^ORCID,Frere Justin J.¹^ORCID,Brown Julia A.¹,Nachbagauer Raffael¹^ORCID,Foster Gregory A.³,Krysztof David³^ORCID,Tortorella Domenico¹^ORCID,Stramer Susan L.³,García-Sastre Adolfo¹²⁴^ORCID,Krammer Florian¹^ORCID,Lim Jean K.¹^ORCID

Affiliation:

1. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

2. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

3. American Red Cross, Gaithersburg, MD 20877, USA.

4. Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

Abstract

One antibody for all and all antibodies for one Antibodies against related flavi-viruses such as dengue (DENV) and West Nile (WNV) can cross-react with Zika virus (ZIKV) and could thereby increase disease severity. Bardina et al. tested whether DENV and WNV antibodies from humans, or even yellow fever vaccination, could enhance ZIKV infection. In a mouse model, low titers of DENV and WNV antibodies enhanced ZIKV viremia, especially in the spinal cord and testes, whereas high titers remained protective. Generally, WNV antibodies were less disease-enhancing than DENV antibodies, and, in macaques, yellow fever vaccination had very little effect. Science , this issue p. 175

Funder

National Institute of Allergy and Infectious Diseases

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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2. Pathogenesis of Dengue: Challenges to Molecular Biology

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