Synthetic Genetic Polymers Capable of Heredity and Evolution

Author:

Pinheiro Vitor B.1,Taylor Alexander I.1,Cozens Christopher1,Abramov Mikhail2,Renders Marleen2,Zhang Su3,Chaput John C.3,Wengel Jesper4,Peak-Chew Sew-Yeu1,McLaughlin Stephen H.1,Herdewijn Piet2,Holliger Philipp1

Affiliation:

1. Medical Research Council (MRC) Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK.

2. Rega Institute, Katholieke Universiteit Leuven, Minderbroederstraat 10, B 3000, Leuven, Belgium.

3. Center for Evolutionary Medicine and Informatics, The Biodesign Institute at Arizona State University, 1001 South McAllister Avenue, Tempe, AZ 85287–5301, USA.

4. Nucleic Acid Center, Department of Physics and Chemistry, University of Southern Denmark, Campusvej 55, DK-5230 Odense M, Denmark.

Abstract

Unnatural Bases The genetic basis of all life on the planet is comprised of deoxyribonucleic acid (DNA) with four nitrogenous nucleotide bases, abbreviated to A, G, C, and T. But there are variations on this theme, and Pinheiro et al. (p. 341 ; see the Perspective by Joyce ) describe the directed evolution of unnatural nucleic acid–like genetic polymers. Variant enzymes were developed that efficiently transcribed DNA to anhydrohexitol (HNA), cyclohexenyl (CeNA), locked (LNA), and threofuranosyl (TNA) nuceic acid analogs. Further variant enzymes were developed to reverse-transcribe these analogs back to DNA. Thus, man-made nucleic acid analogs can be designed and selected that have the potential to operate in a way analogous to the natural process of heredity and evolution.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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