Synthetic Genetic Polymers Capable of Heredity and Evolution-Reference-Cited by-同舟云学术

Synthetic Genetic Polymers Capable of Heredity and Evolution

Published:2012-04-20 Issue:6079 Volume:336 Page:341-344
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Pinheiro Vitor B.¹,Taylor Alexander I.¹,Cozens Christopher¹,Abramov Mikhail²,Renders Marleen²,Zhang Su³,Chaput John C.³,Wengel Jesper⁴,Peak-Chew Sew-Yeu¹,McLaughlin Stephen H.¹,Herdewijn Piet²,Holliger Philipp¹

Affiliation:

1. Medical Research Council (MRC) Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK.

2. Rega Institute, Katholieke Universiteit Leuven, Minderbroederstraat 10, B 3000, Leuven, Belgium.

3. Center for Evolutionary Medicine and Informatics, The Biodesign Institute at Arizona State University, 1001 South McAllister Avenue, Tempe, AZ 85287–5301, USA.

4. Nucleic Acid Center, Department of Physics and Chemistry, University of Southern Denmark, Campusvej 55, DK-5230 Odense M, Denmark.

Abstract

Unnatural Bases The genetic basis of all life on the planet is comprised of deoxyribonucleic acid (DNA) with four nitrogenous nucleotide bases, abbreviated to A, G, C, and T. But there are variations on this theme, and Pinheiro et al. (p. 341 ; see the Perspective by

Joyce

) describe the directed evolution of unnatural nucleic acid–like genetic polymers. Variant enzymes were developed that efficiently transcribed DNA to anhydrohexitol (HNA), cyclohexenyl (CeNA), locked (LNA), and threofuranosyl (TNA) nuceic acid analogs. Further variant enzymes were developed to reverse-transcribe these analogs back to DNA. Thus, man-made nucleic acid analogs can be designed and selected that have the potential to operate in a way analogous to the natural process of heredity and evolution.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference62 articles.

1. Chemical Etiology of Nucleic Acid Structure

2. Discovery, Characterization, and Optimization of an Unnatural Base Pair for Expansion of the Genetic Alphabet

3. DNA Analogues with Nonphosphodiester Backbones

4. Chemical Etiology of Nucleic Acid Structure: The α-Threofuranosyl-(3'→2') Oligonucleotide System

5. Nucleic Acids with a Six-Membered ‘Carbohydrate’ Mimic in the Backbone

Cited by 615 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Exploring the molecular aspect and updating evolutionary approaches to the DNA polymerase enzymes for biotechnological needs: A comprehensive review;International Journal of Biological Macromolecules;2024-09

2. Analysis and control of untemplated DNA polymerase activity for guided synthesis of kilobase-scale DNA sequences;2024-08-30

3. Template-independent synthesis and 3′-end labelling of 2′-modified oligonucleotides with terminal deoxynucleotidyl transferases;Nucleic Acids Research;2024-08-16

4. Xeno Nucleic Acids as Functional Materials: From Biophysical Properties to Application;Advanced Healthcare Materials;2024-07-22

5. Synthesis of Seven-Membered Ring Nucleosides and Serendipitous Simmons–Smith O-Glycosylation;Organic Letters;2024-06-12