Correction of Sickle Cell Disease in Adult Mice by Interference with Fetal Hemoglobin Silencing-Reference-Cited by-同舟云学术

Correction of Sickle Cell Disease in Adult Mice by Interference with Fetal Hemoglobin Silencing

Published:2011-11-18 Issue:6058 Volume:334 Page:993-996
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Xu Jian¹²,Peng Cong¹,Sankaran Vijay G.¹³,Shao Zhen¹,Esrick Erica B.¹⁴,Chong Bryan G.¹,Ippolito Gregory C.⁵,Fujiwara Yuko¹²,Ebert Benjamin L.⁴,Tucker Philip W.⁵,Orkin Stuart H.¹²

Affiliation:

1. Division of Hematology/Oncology, Children’s Hospital Boston and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Stem Cell Institute, Harvard Medical School, Boston, MA 02115, USA.

2. Howard Hughes Medical Institute, Boston, MA 02115, USA.

3. Broad Institute and Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.

4. Dana-Farber Cancer Institute, Brigham and Women’s Hospital, Harvard Stem Cell Institute, Harvard Medical School, Boston, MA 02115, USA.

5. Institute for Cellular and Molecular Biology, The University of Texas at Austin, Austin, TX 78712, USA.

Abstract

Manipulation of a transcriptional repressor promotes expression of protective fetal globin genes.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference43 articles.

1. Two Families Showing Interaction of Haemoglobin C or Thalassaemia with High Foetal Haemoglobin in Adults

2. Hereditary Persistence of Fetal Hemoglobin: A Study of 79 Affected Persons in 15 Negro Families in Baltimore

3. A Specific Chemical Difference Between the Globins of Normal Human and Sickle-Cell Anæmia Hæmoglobin

4. Mortality In Sickle Cell Disease -- Life Expectancy and Risk Factors for Early Death

5. A QTL influencing F cell production maps to a gene encoding a zinc-finger protein on chromosome 2p15

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