Broad and Potent Neutralizing Antibodies from an African Donor Reveal a New HIV-1 Vaccine Target

Author:

Walker Laura M.1,Phogat Sanjay K.2,Chan-Hui Po-Ying3,Wagner Denise2,Phung Pham4,Goss Julie L.4,Wrin Terri4,Simek Melissa D.5,Fling Steven1,Mitcham Jennifer L.3,Lehrman Jennifer K.5,Priddy Frances H.5,Olsen Ole A.3,Frey Steven M.3,Hammond Phillip W.3,Kaminsky Stephen2,Zamb Timothy2,Moyle Matthew3,Koff Wayne C.5,Poignard Pascal1,Burton Dennis R.16,

Affiliation:

1. Department of Immunology and Microbial Science, and IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.

2. AIDS Vaccine Design and Development Laboratory, International AIDS Vaccine Initiative, New York, NY 11220, USA.

3. Theraclone Sciences, Seattle, WA 98104, USA.

4. Monogram Biosciences, Inc., South San Francisco, CA 94080, USA.

5. International AIDS Vaccine Initiative, New York, NY 10038, USA.

6. Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard, Boston, MA 02114, USA.

Abstract

Anti-HIV Antibodies One of the top priorities for an HIV vaccine is the ability to elicit a broadly neutralizing antibody response, which should provide the best protection against infection. In the 25 years since the discovery of HIV, very few broadly neutralizing antibodies have been identified, and those that do exist were discovered nearly two decades ago. Using a high-throughput culture system, Walker et al. (p. 285 ; published online 3 September) now identify two additional broadly neutralizing antibodies isolated from a clade A HIV-infected African donor. These antibodies exhibit great potency and, in contrast to other known broadly neutralizing antibodies, are able to neutralize a wide range of viruses from many different clades. The antibodies recognize a motif in the trimerized viral envelope protein that is found in conserved regions of the variable loops of the gp120 subunit. Identification of this motif provides an intriguing new target for vaccine development.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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