Transgenic Monkeys Produced by Retroviral Gene Transfer into Mature Oocytes-Reference-Cited by-全球学者库

Transgenic Monkeys Produced by Retroviral Gene Transfer into Mature Oocytes

Published:2001-01-12 Issue:5502 Volume:291 Page:309-312
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Chan A. W. S.¹,Chong K. Y.¹,Martinovich C.¹,Simerly C.¹,Schatten G.¹

Affiliation:

1. Oregon Regional Primate Research Center, Center for Women's Health, and Departments of Cell-Developmental Biology and Obstetrics-Gynecology, Oregon Health Sciences University, 505 NW 185th Avenue, Beaverton, OR 97006, USA.

Abstract

Transgenic rhesus monkeys carrying the green fluorescent protein (GFP) gene were produced by injecting pseudotyped replication-defective retroviral vector into the perivitelline space of 224 mature rhesus oocytes, later fertilized by intracytoplasmic sperm injection. Of the three males born from 20 embryo transfers, one was transgenic when accessible tissues were assayed for transgene DNA and messenger RNA. All tissues that were studied from a fraternal set of twins, miscarried at 73 days, carried the transgene, as confirmed by Southern analyses, and the GFP transgene reporter was detected by both direct and indirect fluorescence imaging.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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