Interfollicular Epidermal Stem Cells Self-Renew via Autocrine Wnt Signaling-Reference-Cited by-同舟云学术

Interfollicular Epidermal Stem Cells Self-Renew via Autocrine Wnt Signaling

Published:2013-12-06 Issue:6163 Volume:342 Page:1226-1230
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Lim Xinhong¹,Tan Si Hui²,Koh Winston Lian Chye³,Chau Rosanna Man Wah³,Yan Kelley S.⁴,Kuo Calvin J.⁴,van Amerongen Renée¹,Klein Allon Moshe⁵,Nusse Roel¹

Affiliation:

1. Department of Developmental Biology, Howard Hughes Medical Institute (HHMI), Institute for Stem Cell Biology and Regenerative Medicine, School of Medicine, Stanford University, Stanford, CA, USA.

2. Program in Cancer Biology, School of Medicine, Stanford University, Stanford, CA, USA.

3. Department of Bio-engineering, Stanford University, Stanford, CA, USA.

4. Department of Medicine, School of Medicine, Stanford University, Stanford, CA, USA.

5. Department of Systems Biology, Harvard Medical School, Boston, MA, USA.

Abstract

Epithelial Stem Cells Much remains to be known about how epithelial stem cells are generated and maintained. Lim et al. (p. 1226 ; see the Perspective by

Frede and Jones

) describe a mechanism of stem cell maintenance where epidermal stem cells generate their own self-renewing Wnt signals rather than being controlled by adjacent “niche” signals. These stem cells also express secreted Wnt inhibitors that become localized to more differentiated progeny cells. These autocrine Wnt signals and paracrine long-range Wnt inhibitors may balance stem cell self-renewal and differentiation.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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