Segregation of Transcription and Replication Sites Into Higher Order Domains-Reference-Cited by-同舟云学术

Segregation of Transcription and Replication Sites Into Higher Order Domains

Published:1998-09-04 Issue:5382 Volume:281 Page:1502-1505
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Wei Xiangyun¹,Samarabandu Jagath¹,Devdhar Rakendu S.¹,Siegel Alan J.¹,Acharya Raj¹,Berezney Ronald¹

Affiliation:

1. X. Wei, J. Samarabandu, A. J. Siegel, R. Berezney, Departments of Biological Sciences, State University of New York at Buffalo, Buffalo, NY 14260, USA. R. S. Devdhar and R. Acharya, Department of Electrical and Computer Engineering, State University of New York at Buffalo, Buffalo, NY 14260, USA.

Abstract

Microscopy shows that individual sites of DNA replication and transcription of mammalian nuclei segregate into sets of roughly 22 and 16 higher order domains, respectively. Each domain set displayed a distinct network-like appearance, including regions of individual domains and interdigitation of domains between the two networks. These data support a dynamic mosaic model for the higher order arrangement of genomic function inside the cell nuclei.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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