Evolutionary changes in promoter and enhancer activity during human corticogenesis-Reference-Cited by-同舟云学术

Evolutionary changes in promoter and enhancer activity during human corticogenesis

Published:2015-03-06 Issue:6226 Volume:347 Page:1155-1159
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Reilly Steven K.¹,Yin Jun¹,Ayoub Albert E.²³,Emera Deena¹,Leng Jing¹⁴,Cotney Justin¹,Sarro Richard¹,Rakic Pasko²³,Noonan James P.¹²⁴

Affiliation:

1. Department of Genetics, Yale School of Medicine, New Haven, CT 06510, USA.

2. Kavli Institute for Neuroscience, Yale School of Medicine, New Haven, CT 06510, USA.

3. Department of Neurobiology, Yale School of Medicine, New Haven, CT 06510, USA.

4. Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT 06511, USA.

Abstract

Of mice, men, and macaque brains The human brain represents a unique evolutionary trajectory. To better understand how the human brain came to be, Reilly et al. sought to identify changes in gene expression between mice, macaques, and humans. They compared epigenetic marks in the embryonic cortex, which revealed changes in gene regulation in biological pathways associated with cortical development. Science , this issue p. 1155

Funder

NSF

NIH

Wellcome Trust

Medical Research Council

Brown Coxe Fellowship in the Medical Sciences

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference43 articles.

1. Cortical Evolution: Judge the Brain by Its Cover