Structural Basis for Tail-Anchored Membrane Protein Biogenesis by the Get3-Receptor Complex

Author:

Stefer Susanne1,Reitz Simon2,Wang Fei3,Wild Klemens2,Pang Yin-Yuin2,Schwarz Daniel4,Bomke Jörg4,Hein Christopher1,Löhr Frank1,Bernhard Frank1,Denic Vladimir3,Dötsch Volker1,Sinning Irmgard2

Affiliation:

1. Institute for Biophysical Chemistry, Centre for Biomolecular Magnetic Resonance, Goethe University, D-60325 Frankfurt am Main, Germany.

2. Heidelberg University Biochemistry Center (BZH), Im Neuenheimer Feld 328, D-69120 Heidelberg, Germany.

3. Department of Molecular and Cellular Biology, Harvard University, Northwest Laboratories, Cambridge, MA 02138, USA.

4. Merck KGaA, Merck Serono, Molecular Interactions and Biophysics, D-64293 Darmstadt, Germany.

Abstract

Docking of cytoplasmic and membrane receptors facilitates conformational changes that drive protein insertion.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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