Functional Adaptation of BabA, the H. pylori ABO Blood Group Antigen Binding Adhesin-Reference-Cited by-同舟云学术

Functional Adaptation of BabA, the H. pylori ABO Blood Group Antigen Binding Adhesin

Published:2004-07-23 Issue:5683 Volume:305 Page:519-522
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Aspholm-Hurtig Marina¹²³⁴⁵,Dailide Giedrius¹²³⁴⁵,Lahmann Martina¹²³⁴⁵,Kalia Awdhesh¹²³⁴⁵,Ilver Dag¹²³⁴⁵,Roche Niamh¹²³⁴⁵,Vikström Susanne¹²³⁴⁵,Sjöström Rolf¹²³⁴⁵,Lindén Sara¹²³⁴⁵,Bäckström Anna¹²³⁴⁵,Lundberg Carina¹²³⁴⁵,Arnqvist Anna¹²³⁴⁵,Mahdavi Jafar¹²³⁴⁵,Nilsson Ulf J.¹²³⁴⁵,Velapatiño Billie¹²³⁴⁵,Gilman Robert H.¹²³⁴⁵,Gerhard Markus¹²³⁴⁵,Alarcon Teresa¹²³⁴⁵,López-Brea Manuel¹²³⁴⁵,Nakazawa Teruko¹²³⁴⁵,Fox James G.¹²³⁴⁵,Correa Pelayo¹²³⁴⁵,Dominguez-Bello Maria Gloria¹²³⁴⁵,Perez-Perez Guillermo I.¹²³⁴⁵,Blaser Martin J.¹²³⁴⁵,Normark Staffan¹²³⁴⁵,Carlstedt Ingemar¹²³⁴⁵,Oscarson Stefan¹²³⁴⁵,Teneberg Susann¹²³⁴⁵,Berg Douglas E.¹²³⁴⁵,Borén Thomas¹²³⁴⁵

Affiliation:

1. Department of Odontology, section of Oral Microbiology, Umeå University, SE-901 87 Umeå, Sweden.

2. Department of Molecular Microbiology, Washington University Medical School, St. Louis, MO 63110, USA.

3. Department of Chemistry, Göteborg University, SE-412 96 Göteborg, Sweden.

4. Institute of Medical Biochemistry, Göteborg University, SE-405 30 Göteborg, Sweden.

5. Department of Cell and Molecular Biology, Lund University, SE-221 84 Lund, Sweden.

Abstract

Adherence by Helicobacter pylori increases the risk of gastric disease. Here, we report that more than 95% of strains that bind fucosylated blood group antigen bind A, B, and O antigens (generalists), whereas 60% of adherent South American Amerindian strains bind blood group O antigens best (specialists). This specialization coincides with the unique predominance of blood group O in these Amerindians. Strains differed about 1500-fold in binding affinities, and diversifying selection was evident in babA sequences. We propose that cycles of selection for increased and decreased bacterial adherence contribute to babA diversity and that these cycles have led to gradual replacement of generalist binding by specialist binding in blood group O–dominant human populations.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference17 articles.

1. Helicobacter pylori and gastrointestinal tract adenocarcinomas

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