Knowing Where and Getting There: A Human Navigation Network-Reference-Cited by-同舟云学术

Knowing Where and Getting There: A Human Navigation Network

Published:1998-05-08 Issue:5365 Volume:280 Page:921-924
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Maguire Eleanor A.¹²,Burgess Neil¹²,Donnett James G.¹²,Frackowiak Richard S. J.¹²,Frith Christopher D.¹²,O'Keefe John¹²

Affiliation:

1. E. A. Maguire, R. S. J. Frackowiak, C. D. Frith, Wellcome Department of Cognitive Neurology, Institute of Neurology, University College London, 12 Queen Square, London WC1N 3BG, UK.

2. N. Burgess, J. G. Donnett, J. O'Keefe, Department of Anatomy and Developmental Biology and Institute of Cognitive Neuroscience, University College London, Gower Street, London WC1E 6BT, UK.

Abstract

The neural basis of navigation by humans was investigated with functional neuroimaging of brain activity during navigation in a familiar, yet complex virtual reality town. Activation of the right hippocampus was strongly associated with knowing accurately where places were located and navigating accurately between them. Getting to those places quickly was strongly associated with activation of the right caudate nucleus. These two right-side brain structures function in the context of associated activity in right inferior parietal and bilateral medial parietal regions that support egocentric movement through the virtual town, and activity in other left-side regions (hippocampus, frontal cortex) probably involved in nonspatial aspects of navigation. These findings outline a network of brain areas that support navigation in humans and link the functions of these regions to physiological observations in other mammals.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference25 articles.

1. J. O'Keefe and Dostrovsky J., Brain Res. 34, 171 (1971).

2. Taube J. S., Muller R. U., Ranck J. B., J. Neurosci.10, 420 (1990).

3. J. O'Keefe and L. Nadel The Hippocampus as a Cognitive Map (Clarendon Oxford 1978).

4. Anderson R. A., Philos. Trans. R. Soc. London Ser. B352, 1421 (1997); H. O. Karnath, ibid., p. 1411; G. Vallar, ibid., p. 1401.

5. S. I. Wiener, J. Neurosci. 13, 3802 (1993); Devan B. D., Goad E. H., Petri H. L., Neurobiol. Learn. Mem. 66, 305 (1996); M. Potegal,Spatial Abilities: Development and Physiological Foundations (Academic Press, New York, 1982).

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