Structural Basis of Type II Topoisomerase Inhibition by the Anticancer Drug Etoposide-Reference-Cited by-同舟云学术

Structural Basis of Type II Topoisomerase Inhibition by the Anticancer Drug Etoposide

Published:2011-07-22 Issue:6041 Volume:333 Page:459-462
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Wu Chyuan-Chuan¹,Li Tsai-Kun²³,Farh Lynn⁴,Lin Li-Ying¹⁵,Lin Te-Sheng¹⁵,Yu Yu-Jen¹,Yen Tien-Jui¹,Chiang Chia-Wang¹⁵,Chan Nei-Li¹⁵

Affiliation:

1. Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Taipei City 100, Taiwan.

2. Department and Graduate Institute of Microbiology, College of Medicine, National Taiwan University, Taipei City 100, Taiwan.

3. Center for Biotechnology, National Taiwan University, Taipei City 106, Taiwan.

4. Department of Chemical Biology, National Pingtung University of Education, Pingtung, Pingtung County 900, Taiwan.

5. Institute of Biochemistry, College of Life Sciences, National Chung Hsing University, Taichung 402, Taiwan.

Abstract

Inhibition of an enzyme that alters DNA topology with an anticancer agent should facilitate development of better cancer drugs.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference35 articles.

1. Cellular roles of DNA topoisomerases: a molecular perspective

2. J. C. Wang Untangling the Double Helix: DNA Entanglement and the Action of the DNA Topoisomerases (Cold Spring Harbor Laboratory Press Cold Spring Harbor NY 2009).

3. Analysis of the eukaryotic topoisomerase II DNA gate: a single-molecule FRET and structural perspective

4. DNA topoisomerases: harnessing and constraining energy to govern chromosome topology

5. Involvement of nucleic acid synthesis in cell killing mechanisms of topoisomerase poisons;D’Arpa P.;Cancer Res.,1990

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