Affiliation:
1. Department of Physics, Graduate School of Science, University of Tokyo, 7-3-1 Hongo Bunkyou-ku Tokyo, 113-0033 Japan.
Abstract
Measuring Single Myosins at Work
In the past 15 years, the molecular mechanism of muscle contraction has been investigated at the single-molecule level; however, results have varied between laboratories because of the nonprocessive properties of skeletal myosin. Now,
Kaya and Higuchi
(p.
686
) have measured the nonlinear elasticity and working stroke size of single skeletal myosins by combining optical trapping and fluorescence imaging with subnanometer accuracy. The data suggest that it is important to relate myosin's internal structural changes to physiological force generation and filament sliding.
Publisher
American Association for the Advancement of Science (AAAS)
Cited by
152 articles.
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