Neutralization of SARS-CoV-2 Omicron by BNT162b2 mRNA vaccine–elicited human sera-Reference-Cited by-同舟云学术

Neutralization of SARS-CoV-2 Omicron by BNT162b2 mRNA vaccine–elicited human sera

Published:2022-02-11 Issue:6581 Volume:375 Page:678-680
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Muik Alexander¹^ORCID,Lui Bonny Gaby¹,Wallisch Ann-Kathrin¹^ORCID,Bacher Maren¹,Mühl Julia¹^ORCID,Reinholz Jonas¹^ORCID,Ozhelvaci Orkun¹^ORCID,Beckmann Nina¹,Güimil Garcia Ramón de la Caridad¹^ORCID,Poran Asaf²^ORCID,Shpyro Svetlana¹,Finlayson Andrew¹^ORCID,Cai Hui³,Yang Qi³^ORCID,Swanson Kena A.³^ORCID,Türeci Özlem¹⁴^ORCID,Şahin Uğur¹⁵^ORCID

Affiliation:

1. BioNTech, An der Goldgrube 12, 55131 Mainz, Germany.

2. BioNTech US, 40 Erie Street, Cambridge, MA 02139, USA.

3. Pfizer, 401 N Middletown Rd., Pearl River, NY 10960, USA.

4. HI-TRON – Helmholtz Institute for Translational Oncology Mainz by DKFZ, Obere Zahlbacherstr. 63, 55131 Mainz, Germany.

5. TRON gGmbH – Translational Oncology at the University Medical Center of the Johannes Gutenberg University, Freiligrathstraße 12, 55131 Mainz, Germany.

Abstract

The globally circulating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant of concern Omicron (B.1.1.529) has a large number of mutations, especially in the spike protein, indicating that recognition by neutralizing antibodies may be compromised. We tested Wuhan (Wuhan-Hu-1 reference strain), Beta (B.1.351), Delta (B.1.617.2), or Omicron pseudoviruses with sera of 51 participants who received two or three doses of the messenger RNA (mRNA)–based COVID-19 vaccine BNT162b2. After two doses, Omicron-neutralizing titers were reduced >22-fold compared with Wuhan-neutralizing titers. One month after the third vaccine dose, Omicron-neutralizing titers were increased 23-fold relative to their levels after two doses and were similar to levels of Wuhan-neutralizing titers after two doses. The requirement of a third vaccine dose to effectively neutralize Omicron was confirmed with sera from a subset of participants using live SARS-CoV-2. These data suggest that three doses of the mRNA vaccine BNT162b2 may protect against Omicron-mediated COVID-19.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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