Functional Coherence of the Human Y Chromosome-Reference-Cited by-同舟云学术

Functional Coherence of the Human Y Chromosome

Published:1997-10-24 Issue:5338 Volume:278 Page:675-680
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Lahn Bruce T.¹,Page David C.¹

Affiliation:

1. Howard Hughes Medical Institute, Whitehead Institute, and Department of Biology, Massachusetts Institute of Technology, 9 Cambridge Center, Cambridge, MA 02142, USA.

Abstract

A systematic search of the nonrecombining region of the human Y chromosome (NRY) identified 12 novel genes or families, 10 with full-length complementary DNA sequences. All 12 genes, and six of eight NRY genes or families previously isolated by less systematic means, fell into two classes. Genes in the first group were expressed in many organs; these housekeeping genes have X homologs that escape X inactivation. The second group, consisting of Y-chromosomal gene families expressed specifically in testes, may account for infertility among men with Y deletions. The coherence of the NRY's gene content contrasts with the apparently haphazard content of most eukaryotic chromosomes.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference81 articles.

1. The remaining 5% of the chromosome is composed of two pseudoautosomal regions that maintain sequence identity with the X chromosome by meiotic recombination [

2. Cooke H. J., Brown W. R., Rappold G. A., Nature 317, 687 (1985);

3. ; M. C. Simmler et al. ibid. p. 692; D. Freije

4. Helms C., Watson M. S., Donis-Keller H., Science 258, 1784 (1992);

5. Affara N. A., et al., Cytogenet. Cell Genet. 73, 33 (1996);

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