A Map of the Interactome Network of the Metazoan C. elegans-Reference-Cited by-同舟云学术

A Map of the Interactome Network of the Metazoan C. elegans

Published:2004-01-23 Issue:5657 Volume:303 Page:540-543
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Li Siming¹²³⁴⁵,Armstrong Christopher M.¹²³⁴⁵,Bertin Nicolas¹²³⁴⁵,Ge Hui¹²³⁴⁵,Milstein Stuart¹²³⁴⁵,Boxem Mike¹²³⁴⁵,Vidalain Pierre-Olivier¹²³⁴⁵,Han Jing-Dong J.¹²³⁴⁵,Chesneau Alban¹²³⁴⁵,Hao Tong¹²³⁴⁵,Goldberg Debra S.¹²³⁴⁵,Li Ning¹²³⁴⁵,Martinez Monica¹²³⁴⁵,Rual Jean-François¹²³⁴⁵,Lamesch Philippe¹²³⁴⁵,Xu Lai¹²³⁴⁵,Tewari Muneesh¹²³⁴⁵,Wong Sharyl L.¹²³⁴⁵,Zhang Lan V.¹²³⁴⁵,Berriz Gabriel F.¹²³⁴⁵,Jacotot Laurent¹²³⁴⁵,Vaglio Philippe¹²³⁴⁵,Reboul Jérôme¹²³⁴⁵,Hirozane-Kishikawa Tomoko¹²³⁴⁵,Li Qianru¹²³⁴⁵,Gabel Harrison W.¹²³⁴⁵,Elewa Ahmed¹²³⁴⁵,Baumgartner Bridget¹²³⁴⁵,Rose Debra J.¹²³⁴⁵,Yu Haiyuan¹²³⁴⁵,Bosak Stephanie¹²³⁴⁵,Sequerra Reynaldo¹²³⁴⁵,Fraser Andrew¹²³⁴⁵,Mango Susan E.¹²³⁴⁵,Saxton William M.¹²³⁴⁵,Strome Susan¹²³⁴⁵,van den Heuvel Sander¹²³⁴⁵,Piano Fabio¹²³⁴⁵,Vandenhaute Jean¹²³⁴⁵,Sardet Claude¹²³⁴⁵,Gerstein Mark¹²³⁴⁵,Doucette-Stamm Lynn¹²³⁴⁵,Gunsalus Kristin C.¹²³⁴⁵,Harper J. Wade¹²³⁴⁵,Cusick Michael E.¹²³⁴⁵,Roth Frederick P.¹²³⁴⁵,Hill David E.¹²³⁴⁵,Vidal Marc¹²³⁴⁵

Affiliation:

1. Dana-Farber Cancer Institute and Department of Genetics, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA.

2. Institut de Génétique Moléculaire, Centre National de la Recherche Scientifique UMR 5535, 1919 Route de Mende, 34293 Montpellier Cedex 5, France.

3. Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 250 Longwood Avenue, Boston, MA 02115, USA.

4. Unité de Recherche en Biologie Moléculaire, Facultés Notre-Dame de la Paix, 61 Rue de Bruxelles, 5000 Namur, Belgium.

5. Verna and Marrs Department of Biochemistry and Molecular Biology, Program in Cell and Molecular Biology, Biophysics, and Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.

Abstract

To initiate studies on how protein-protein interaction (or “interactome”) networks relate to multicellular functions, we have mapped a large fraction of the Caenorhabditis elegans interactome network. Starting with a subset of metazoan-specific proteins, more than 4000 interactions were identified from high-throughput, yeast two-hybrid (HT=Y2H) screens. Independent coaffinity purification assays experimentally validated the overall quality of this Y2H data set. Together with already described Y2H interactions and interologs predicted in silico , the current version of the Worm Interactome (WI5) map contains ∼5500 interactions. Topological and biological features of this interactome network, as well as its integration with phenome and transcriptome data sets, lead to numerous biological hypotheses.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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