Requirement for Coronin 1 in T Lymphocyte Trafficking and Cellular Homeostasis-Reference-Cited by-同舟云学术

Requirement for Coronin 1 in T Lymphocyte Trafficking and Cellular Homeostasis

Published:2006-08-11 Issue:5788 Volume:313 Page:839-842
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Föger Niko¹²,Rangell Linda¹²,Danilenko Dimitry M.¹²,Chan Andrew C.¹²

Affiliation:

1. Department of Immunology, Genentech, Incorporated, 1 DNA Way, South San Francisco, CA 94080, USA.

2. Department of Pathology, Genentech, Incorporated, 1 DNA Way, South San Francisco, CA 94080, USA.

Abstract

The evolutionarily conserved actin-related protein (Arp2/3) complex is a key component of actin filament networks that is dynamically regulated by nucleation-promoting and inhibitory factors. Although much is known about actin assembly, the physiologic functions of inhibitory proteins are unclear. We generated coronin 1 –/– mice and found that coronin 1 exerted an inhibitory effect on cellular steady-state F-actin formation via an Arp2/3-dependent mechanism. Whereas coronin 1 was required for chemokine-mediated migration, it was dispensable for T cell antigen receptor functions in T cells. Moreover, actin dynamics, through a mitochondrial pathway, was linked to lymphocyte homeostasis.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference26 articles.

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5. Inhibition of the Arp2/3 complex-nucleated actin polymerization and branch formation by tropomyosin

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