Molecular programs of regional specification and neural stem cell fate progression in macaque telencephalon

Author:

Micali Nicola1ORCID,Ma Shaojie1ORCID,Li Mingfeng12ORCID,Kim Suel-Kee1ORCID,Mato-Blanco Xoel3ORCID,Sindhu Suvimal Kumar1ORCID,Arellano Jon I.1ORCID,Gao Tianliuyun1ORCID,Shibata Mikihito1,Gobeske Kevin T.1,Duque Alvaro1,Santpere Gabriel3ORCID,Sestan Nenad145ORCID,Rakic Pasko15ORCID

Affiliation:

1. Department of Neuroscience, Yale School of Medicine, New Haven, CT 06520, USA.

2. Department of Pharmacology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, 430030, Wuhan, China.

3. Hospital del Mar Research Institute, Parc de Recerca Biomèdica de Barcelona (PRBB), 08003 Barcelona, Catalonia, Spain.

4. Departments of Psychiatry, Genetics and Comparative Medicine, Wu Tsai Institute, Program in Cellular Neuroscience, Neurodegeneration and Repair, and Yale Child Study Center, Yale School of Medicine, New Haven, CT 06510, USA.

5. Kavli Institute for Neuroscience, Yale School of Medicine, New Haven, CT 06520, USA.

Abstract

During early telencephalic development, intricate processes of regional patterning and neural stem cell (NSC) fate specification take place. However, our understanding of these processes in primates, including both conserved and species-specific features, remains limited. Here, we profiled 761,529 single-cell transcriptomes from multiple regions of the prenatal macaque telencephalon. We deciphered the molecular programs of the early organizing centers and their cross-talk with NSCs, revealing primate-biased galanin-like peptide ( GALP ) signaling in the anteroventral telencephalon. Regional transcriptomic variations were observed along the frontotemporal axis during early stages of neocortical NSC progression and in neurons and astrocytes. Additionally, we found that genes associated with neuropsychiatric disorders and brain cancer risk might play critical roles in the early telencephalic organizers and during NSC progression.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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