Targeting a ceramide double bond improves insulin resistance and hepatic steatosis-Reference-Cited by-同舟云学术

Targeting a ceramide double bond improves insulin resistance and hepatic steatosis

Published:2019-07-26 Issue:6451 Volume:365 Page:386-392
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Chaurasia Bhagirath¹^ORCID,Tippetts Trevor S.¹^ORCID,Mayoral Monibas Rafael²^ORCID,Liu Jinqi²^ORCID,Li Ying¹^ORCID,Wang Liping¹^ORCID,Wilkerson Joseph L.¹^ORCID,Sweeney C. Rufus¹,Pereira Renato Felipe³,Sumida Doris Hissako³^ORCID,Maschek J. Alan⁴^ORCID,Cox James E.⁴^ORCID,Kaddai Vincent¹,Lancaster Graeme Iain⁵,Siddique Monowarul Mobin⁶^ORCID,Poss Annelise¹^ORCID,Pearson Mackenzie⁷^ORCID,Satapati Santhosh²^ORCID,Zhou Heather²,McLaren David G.²,Previs Stephen F.²,Chen Ying²,Qian Ying²^ORCID,Petrov Aleksandr²,Wu Margaret²,Shen Xiaolan²^ORCID,Yao Jun²^ORCID,Nunes Christian N.²^ORCID,Howard Andrew D.²,Wang Liangsu²,Erion Mark D.²,Rutter Jared⁴⁸^ORCID,Holland William L.¹,Kelley David E.²^ORCID,Summers Scott A.¹^ORCID

Affiliation:

1. Department of Nutrition and Integrative Physiology and the Diabetes and Metabolism Research Center, University of Utah, Salt Lake City, UT 84112, USA.

2. Merck Research Laboratories, Merck, Kenilworth, NJ 07033, USA.

3. School of Dentistry, São Paulo State University (UNESP), Araçatuba 16015, Brazil.

4. Department of Biochemistry and the Diabetes and Metabolism Research Center, University of Utah, Salt Lake City, UT 84112, USA.

5. Baker IDI Heart and Diabetes Institute, Melbourne, Victoria 3004, Australia.

6. Faculty of Science, University of Brunei Darussalam, Gadong 1410, Brunei Darussalam.

7. Sciex, Framingham, MA 01701, USA.

8. Howard Hughes Medical Institute, Salt Lake City, UT 84112, USA.

Abstract

Ceramides in focus Excess calorie intake can ultimately lead to a metabolic syndrome that interferes with fat or lipid metabolism. There are many different types of lipids, and it has been widely debated which are the true culprits underlying metabolic disorders. Chaurasia et al. report that ceramides are the major contributor to insulin resistance and fatty liver disease (see the Perspective by Kusminski and Scherer). This appears to be caused by the enzyme dihydroceramide desaturase 1 (DES1), which is normally involved in ceramide production by inserting a double bond into the backbone of the molecule. In mice fed a high-fat diet, deletion of DES1 improved glucose and lipid metabolism. Science , this issue p. 386 ; see also p. 319

Funder

National Institutes of Health

American Diabetes Association

National Institute of Diabetes and Digestive and Kidney Diseases

Juvenile Diabetes Research Foundation International

American Heart Association

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference46 articles.

1. Ceramides – Lipotoxic Inducers of Metabolic Disorders