Crystal structure of a mycobacterial Insig homolog provides insight into how these sensors monitor sterol levels-Reference-Cited by-同舟云学术

Crystal structure of a mycobacterial Insig homolog provides insight into how these sensors monitor sterol levels

Published:2015-07-10 Issue:6244 Volume:349 Page:187-191
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Ren Ruobing¹²³,Zhou Xinhui¹²³,He Yuan¹²³,Ke Meng¹²³,Wu Jianping¹²³,Liu Xiaohui⁴,Yan Chuangye¹²³,Wu Yixuan¹²³,Gong Xin¹²³,Lei Xiaoguang⁴,Yan S. Frank⁵,Radhakrishnan Arun⁶,Yan Nieng¹²³

Affiliation:

1. State Key Laboratory of Membrane Biology, Tsinghua University, Beijing 100084, China.

2. Center for Structural Biology, School of Life Sciences, School of Medicine, Tsinghua University, Beijing 100084, China.

3. Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing 100084, China.

4. National Institute of Biological Sciences, Beijing 102206, China.

5. Molecular Design and Chemical Biology, Therapeutic Modalities, Roche Pharma Research and Early Development, Roche Innovation Center Shanghai, Shanghai 201203, China.

6. Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390-9046, USA.

Abstract

Structure of a sterol sensor The aberrant accumulation of sterols contributes to heart attack and stroke. Two proteins embedded in the membrane of the endoplasmic reticulum, Insig-1 and Insig-2, are key players in the cellular pathway that regulates cellular sterol levels. Ren et al. report the structure of a mycobacterial homolog of Insig. The structure, together with biochemical experiments, suggests how Insig interacts with other components of the sterol regulatory pathway. Science , this issue p. 187

Funder

National Institutes of Health

Welch Foundation

American Heart Association

National Natural Science Foundation of China

Ministry of Science and Technology of China

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference50 articles.

1. A Receptor-Mediated Pathway for Cholesterol Homeostasis