Long-duration hippocampal sharp wave ripples improve memory-Reference-Cited by-同舟云学术

Long-duration hippocampal sharp wave ripples improve memory

Published:2019-06-14 Issue:6445 Volume:364 Page:1082-1086
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Fernández-Ruiz Antonio¹^ORCID,Oliva Azahara¹²^ORCID,Fermino de Oliveira Eliezyer¹³^ORCID,Rocha-Almeida Florbela¹⁴^ORCID,Tingley David¹^ORCID,Buzsáki György¹⁵^ORCID

Affiliation:

1. New York University Neuroscience Institute, New York University, New York, NY 10016, USA.

2. Department of Neuroscience and Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10027, USA.

3. Center for Mathematics, Computing and Cognition, Universidade Federal do ABC, São Bernardo do Campo, São Paulo, Brazil.

4. Division of Neurosciences, University Pablo de Olavide, 41013 Seville, Spain.

5. Center for Neural Science, New York University, New York, NY 10016, USA.

Abstract

Longer ripples make better memories Sharp wave ripples in the hippocampus are thought to play a role in memory formation and action planning. Fernández-Ruiz et al. used multisite electrophysiological recordings combined with optogenetic activation of hippocampal pyramidal neurons in rats performing learning tasks. Learning and correct recall in spatial memory tasks were associated with extended sharp wave ripples. Artificially prolonging these ripples improved working memory performance, whereas aborting the late part of ripples decreased performance. Science , this issue p. 1082

Funder

National Science Foundation

National Institutes of Health

FAPESP

EMBO Postdoctoral Fellowship

Sir Henry Wellcome Postdoctoral Fellowship

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference40 articles.

1. Hippocampal sharp wave‐ripple: A cognitive biomarker for episodic memory and planning