Diminishing Returns Epistasis Among Beneficial Mutations Decelerates Adaptation-Reference-Cited by-同舟云学术

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Diminishing Returns Epistasis Among Beneficial Mutations Decelerates Adaptation

Published:2011-06-03 Issue:6034 Volume:332 Page:1190-1192
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Chou Hsin-Hung¹,Chiu Hsuan-Chao²,Delaney Nigel F.¹,Segrè Daniel²³,Marx Christopher J.¹⁴

Affiliation:

1. Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA.

2. Graduate Program in Bioinformatics, Boston University, Boston, MA 02215, USA.

3. Department of Biology and Department of Biomedical Engineering, Boston University, Boston, MA 02215, USA.

4. Faculty of Arts and Sciences Center for Systems Biology, Harvard University, Cambridge, MA 02138, USA.

Abstract

Interactions between genes reduce the benefits of a mutation and decrease the rate of fitness gain during adaptation.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference18 articles.

1. Epistasis — the essential role of gene interactions in the structure and evolution of genetic systems

2. Epistasis: what it means, what it doesn't mean, and statistical methods to detect it in humans

3. Modular epistasis in yeast metabolism

4. Darwinian Evolution Can Follow Only Very Few Mutational Paths to Fitter Proteins

5. The Biochemical Architecture of an Ancient Adaptive Landscape

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