Activation of Endothelial Cell Protease Activated Receptor 1 by the Protein C Pathway-Reference-Cited by-同舟云学术

Activation of Endothelial Cell Protease Activated Receptor 1 by the Protein C Pathway

Published:2002-06-07 Issue:5574 Volume:296 Page:1880-1882
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Riewald Matthias¹,Petrovan Ramona J.¹,Donner Aaron¹,Mueller Barbara M.²,Ruf Wolfram¹

Affiliation:

1. Department of Immunology, C204, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

2. Division of Cancer Biology, La Jolla Institute for Molecular Medicine, 4570 Executive Drive, San Diego, CA 92121, USA.

Abstract

The coagulant and inflammatory exacerbation in sepsis is counterbalanced by the protective protein C (PC) pathway. Activated PC (APC) was shown to use the endothelial cell PC receptor (EPCR) as a coreceptor for cleavage of protease activated receptor 1 (PAR1) on endothelial cells. Gene profiling demonstrated that PAR1 signaling could account for all APC-induced protective genes, including the immunomodulatory monocyte chemoattractant protein-1 (MCP-1), which was selectively induced by activation of PAR1, but not PAR2. Thus, the prototypical thrombin receptor is the target for EPCR-dependent APC signaling, suggesting a role for this receptor cascade in protection from sepsis.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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