Control of aversion by glycine-gated GluN1/GluN3A NMDA receptors in the adult medial habenula

Author:

Otsu Y.1ORCID,Darcq E.2ORCID,Pietrajtis K.3ORCID,Mátyás F.456ORCID,Schwartz E.3ORCID,Bessaih T.3,Abi Gerges S.3ORCID,Rousseau C. V.1,Grand T.1ORCID,Dieudonné S.1ORCID,Paoletti P.1ORCID,Acsády L.4ORCID,Agulhon C.7ORCID,Kieffer B. L.2ORCID,Diana M. A.3ORCID

Affiliation:

1. Institut de Biologie de l’École Normale Supérieure (IBENS), INSERM U1024, CNRS UMR8197, École Normale Supérieure, Université PSL, 75005 Paris, France.

2. Department of Psychiatry, School of Medicine, Douglas Hospital Research Center, McGill University, Montreal, QC H4H 1R3, Canada.

3. Sorbonne Université, CNRS, INSERM, Neurosciences Paris Seine – Institut de Biologie Paris Seine (NPS-IBPS), 75005 Paris, France.

4. Laboratory of Thalamus Research, Institute of Experimental Medicine, Hungarian Academy of Sciences, 1083 Budapest, Hungary.

5. Research Centre for Natural Sciences Institute of Cognitive Neuroscience and Psychology, 1117 Budapest, Hungary.

6. Department of Anatomy and Histology, University of Veterinary Medicine, 1078 Budapest, Hungary.

7. Integrative Neuroscience and Cognition Center, CNRS UMR8002, Glia-Glia and Glia-Neuron Interactions Group, Paris Descartes University, 75006 Paris, France.

Abstract

An inhibitor causes neuronal excitation Glycine is thought to be primarily an inhibitory neurotransmitter. However, it also acts as a coagonist on excitatory N -methyl-D-aspartate (NMDA) receptors. Otsu et al. examined the function of the NMDA receptor subunit combination GluN1/GluN3A in the medial habenula (MHb) of adult mice. This NMDA receptor subunit combination in MHb neurons is activated by glycine released from astrocytes. Activation of GluN1/GluN3A NMDA receptors causes depolarization and increased spiking of MHb neurons. Reducing GluN3A receptor subunit levels in the MHb blocks conditioned place aversion. Science , this issue p. 250

Funder

National Institute on Drug Abuse

National Institute on Alcohol Abuse and Alcoholism

European Research Council

Agence Nationale de la Recherche

NARSAD Young Investigator Award

Hungarian Science Foundation

Emergence Sorbonne

PICS CNRS

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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