Major subpopulations of Plasmodium falciparum in sub-Saharan Africa-Reference-Cited by-同舟云学术

Major subpopulations of Plasmodium falciparum in sub-Saharan Africa

Published:2019-08-23 Issue:6455 Volume:365 Page:813-816
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Amambua-Ngwa Alfred¹^ORCID,Amenga-Etego Lucas²^ORCID,Kamau Edwin³⁴^ORCID,Amato Roberto⁵⁶^ORCID,Ghansah Anita⁷,Golassa Lemu⁸^ORCID,Randrianarivelojosia Milijaona⁹^ORCID,Ishengoma Deus¹⁰,Apinjoh Tobias¹¹,Maïga-Ascofaré Oumou¹²^ORCID,Andagalu Ben³,Yavo William¹³^ORCID,Bouyou-Akotet Marielle¹⁴^ORCID,Kolapo Oyebola¹¹⁵,Mane Karim¹^ORCID,Worwui Archibald¹^ORCID,Jeffries David¹,Simpson Vikki⁴⁶^ORCID,D’Alessandro Umberto¹^ORCID,Kwiatkowski Dominic⁵⁶^ORCID,Djimde Abdoulaye A.⁵¹⁶^ORCID

Affiliation:

1. Medical Research Council Unit The Gambia at LSHTM, Banjul, The Gambia.

2. West African Centre for Cell Biology of Infectious Pathogens (WACCBIP), University of Ghana, Accra, Ghana.

3. United States Army Medical Research Directorate-Africa, Kenya Medical Research Institute/Walter Reed Project, Kisumu, Kenya.

4. Walter Reed Army Institute of Research, U.S. Military HIV Research Program, Silver Spring, MD, USA.

5. Wellcome Sanger Institute, Hinxton, UK.

6. MRC Centre for Genomics and Global Health, Big Data Institute, University of Oxford, Oxford, UK.

7. Noguchi Memorial Institute for Medical Research (NMIMR), Accra, Ghana.

8. Aklilu Lemma Institute of Pathobiology, Addis Ababa University, Addis Ababa, Ethiopia.

9. Institut Pasteur of Madagascar, Antanarivo, Madagascar.

10. National Institute for Medical Research (NIMR), Tanga, Tanzania.

11. Department of Biochemistry and Molecular Biology, University of Buea, Buea, Cameroon.

12. Bernhard Nocht Institute for Topical Medicine (BNITM), Hamburg, Germany.

13. Unite des Sciences Pharmaceutiques et Biologiques, University Félix Houphouët-Boigny, Abidjan, Côte d’Ivoire.

14. Faculty of Medicine, University of Health Sciences, Libreville, Gabon.

15. Department of Zoology, University of Lagos, Lagos, Nigeria.

16. Malaria Research and Training Centre, University of Science, Techniques and Technologies of Bamako, Bamako, Mali.

Abstract

Ebb and flow of parasite populations The population genetics of the malaria parasite Plasmodium falciparum across Africa is poorly understood but important to know for grasping the risks and dynamics of the spread of drug resistance. Harnessing the power of genomics, Amambua-Ngwa et al. of the Plasmodium Diversity Network Africa found substantial population structure within Africa that is consistent with human and vector population divergence (see the Perspective by Sibley). Specific signatures of selection by antimalarial drugs were detected, along with indications of the effect of colonization and slavery. Furthermore, whole-genome sequencing showed that there is extensive gene flow among the different regions and that Ethiopia has a distinctive population of P. falciparum , which may be indicative of coexistence with another malaria parasite, P. vivax. Science , this issue p. 813 ; see also p. 752

Funder

Wellcome Trust

Medical Research Council

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference31 articles.

1. World Malaria Report 2018 (World Health Organization 2018).

2. Genetic diversity of the African malaria vector Anopheles gambiae

3. The African Genome Variation Project shapes medical genetics in Africa

4. Fragmented Population Structure ofPlasmodium falciparumin a Region of Declining Endemicity

5. Analysis of Plasmodium falciparum diversity in natural infections by deep sequencing

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