VelB/VeA/LaeA Complex Coordinates Light Signal with Fungal Development and Secondary Metabolism-Reference-Cited by-同舟云学术

VelB/VeA/LaeA Complex Coordinates Light Signal with Fungal Development and Secondary Metabolism

Published:2008-06-13 Issue:5882 Volume:320 Page:1504-1506
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Bayram Özgür¹²³⁴,Krappmann Sven¹²³⁴,Ni Min¹²³⁴,Bok Jin Woo¹²³⁴,Helmstaedt Kerstin¹²³⁴,Valerius Oliver¹²³⁴,Braus-Stromeyer Susanna¹²³⁴,Kwon Nak-Jung¹²³⁴,Keller Nancy P.¹²³⁴,Yu Jae-Hyuk¹²³⁴,Braus Gerhard H.¹²³⁴

Affiliation:

1. Institute of Microbiology and Genetics, Georg August University, D-37077 Göttingen, Germany.

2. Department of Bacteriology and Department of Genetics, University of Wisconsin-Madison, Madison, WI 53706, USA.

3. Department of Plant Pathology and Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, WI 53706, USA.

4. Deutsche Forschungsgemeinschaft (DFG) Research Center for Molecular Physiology of the Brain (CMPB), D-37077 Göttingen, Germany.

Abstract

Differentiation and secondary metabolism are correlated processes in fungi that respond to light. In Aspergillus nidulans , light inhibits sexual reproduction as well as secondary metabolism. We identified the heterotrimeric velvet complex VelB/VeA/LaeA connecting light-responding developmental regulation and control of secondary metabolism. VeA, which is primarily expressed in the dark, physically interacts with VelB, which is expressed during sexual development. VeA bridges VelB to the nuclear master regulator of secondary metabolism, LaeA. Deletion of either velB or veA results in defects in both sexual fruiting-body formation and the production of secondary metabolites.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference29 articles.

1. Molecular regulation of penicillin biosynthesis in Aspergillus (Emericella) nidulans

2. J. Hicks, K. Shimizu, N. P. Keller, in The Mycota, vol. 11, F. Kempken, Ed. (Springer, Berlin, 2002), pp. 55–69.

3. Asexual Sporulation in Aspergillus nidulans

4. Functional and Physical Interaction of Blue- and Red-Light Sensors in Aspergillus nidulans

5. G. H. Braus, S. Krappmann, S. Eckert, in Molecular Biology of Fungal Development, H. D. Osiewacz, Ed. (Marcel Dekker, New York, 2002), pp. 215–244.

Cited by 758 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Forest fungi: Secondary metabolism, regulation, function and drug discovery;Forest Fungi;2025

2. Comparative metabolomics analysis reveals specific metabolites associated with the photomorphogenesis of Botrytis cinerea;Postharvest Biology and Technology;2024-12

3. Metabolome and transcriptome unveil the mechanism of light on regulating beauvericin synthesis in Cordyceps chanhua;Fungal Biology;2024-11

4. Role of AplaeA in the regulation of spore production and poly(malic acid) synthesis in Aureobasidium pullulans;International Journal of Biological Macromolecules;2024-11

5. Harnessing biotechnology for penicillin production: Opportunities and environmental considerations;Science of The Total Environment;2024-10