Longitudinal analysis of microbial interaction between humans and the indoor environment

Author:

Lax Simon12,Smith Daniel P.123,Hampton-Marcell Jarrad12,Owens Sarah M.24,Handley Kim M.12,Scott Nicole M.12,Gibbons Sean M.25,Larsen Peter67,Shogan Benjamin D.8,Weiss Sophie910,Metcalf Jessica L.9,Ursell Luke K.911,Vázquez-Baeza Yoshiki91112,Van Treuren Will9,Hasan Nur A.1314,Gibson Molly K.151617,Colwell Rita1314,Dantas Gautam151617,Knight Rob91118,Gilbert Jack A.125

Affiliation:

1. Department of Ecology and Evolution, University of Chicago, 1101 E 57th Street, Chicago, IL 60637, USA.

2. Institute for Genomic and Systems Biology, Argonne National Laboratory, 9700 South Cass Avenue, Argonne, IL 60439, USA.

3. Alkek Center for Metagenomics and Microbiome Research, Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA.

4. Computation Institute, University of Chicago, Chicago, IL 60637, USA.

5. Graduate Program in Biophysical Sciences, University of Chicago, Chicago, IL 60637, USA.

6. Department of Bioscience, Argonne National Laboratory, 9700 South Cass Avenue, Argonne, IL 60439, USA.

7. Department of Bioengineering, University of Illinois at Chicago, Chicago, IL 60607, USA.

8. Department of Surgery, University of Chicago Medicine, 5841 South Maryland Avenue, Chicago, IL 60637, USA.

9. Biofrontiers Institute, University of Colorado, 3415 Colorado Avenue, Boulder, CO 80304, USA.

10. Department of Chemical and Biological Engineering, University of Colorado at Boulder, Boulder, CO 80304, USA.

11. Department of Chemistry and Biochemistry, University of Colorado at Boulder, Boulder, CO 80304, USA.

12. Department of Computer Science, University of Colorado at Boulder, Boulder, CO 80304, USA.

13. CosmosID, 387 Technology Drive, Suite 3119, College Park, MD 20742, USA.

14. Center for Bioinformatics and Computational Biology, University of Maryland Institute for Advanced Computer Studies, University of Maryland College Park, College Park, MD 20742, USA.

15. Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO 63108, USA.

16. Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.

17. Department of Biomedical Engineering, Washington University, St. Louis, MO 63130, USA.

18. Howard Hughes Medical Institute, Boulder, CO 80309, USA.

Abstract

Signature microbes follow you from house to house Householders share more than habitation; they also share inhabitants. In a diverse sample of U.S. homes, Lax et al. found that people and animals sharing homes shared their microbial communities (microbiota) too, probably because of skin shedding and hand and foot contamination. When families moved, their microbiological “aura” followed. If one person left the home even for a few days, their contribution to the microbiome diminished. These findings have implications not only for household identity and composition, but also for indicators of the members' health and well-being. Science , this issue p. 1048

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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