FGF19 as a Postprandial, Insulin-Independent Activator of Hepatic Protein and Glycogen Synthesis-Reference-Cited by-同舟云学术

FGF19 as a Postprandial, Insulin-Independent Activator of Hepatic Protein and Glycogen Synthesis

Published:2011-03-25 Issue:6024 Volume:331 Page:1621-1624
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Kir Serkan¹,Beddow Sara A.²,Samuel Varman T.²,Miller Paul³,Previs Stephen F.³,Suino-Powell Kelly⁴,Xu H. Eric⁴,Shulman Gerald I.²⁵,Kliewer Steven A.¹⁶,Mangelsdorf David J.¹⁷

Affiliation:

1. Department of Pharmacology, University of Texas Southwestern Medical Center, 6001 Forest Park Road, Dallas, TX 75390, USA.

2. Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06510, USA.

3. Department of Nutrition, Case Western Reserve University, Cleveland, Ohio, 44106, USA.

4. Laboratory of Structural Sciences, Van Andel Research Institute, 333 Bostwick Avenue Northeast, Grand Rapids, MI 49503, USA.

5. Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510, USA.

6. Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

7. Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

Abstract

Fibroblast growth factor 19 regulates liver metabolism through a mechanism distinct from that of insulin.

Funder

National Institutes of Health

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Link

http://www.sciencemag.org/content/331/6024/1621.full.pdf

Reference27 articles.

1. The FGF family: biology, pathophysiology and therapy

2. Definition of a novel growth factor-dependent signal cascade for the suppression of bile acid biosynthesis

3. Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis

4. Circulating intestinal fibroblast growth factor 19 has a pronounced diurnal variation and modulates hepatic bile acid synthesis in man

5. Tissue-specific Expression of βKlotho and Fibroblast Growth Factor (FGF) Receptor Isoforms Determines Metabolic Activity of FGF19 and FGF21

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