GRK2-Dependent S1PR1 Desensitization Is Required for Lymphocytes to Overcome Their Attraction to Blood-Reference-Cited by-同舟云学术

GRK2-Dependent S1PR1 Desensitization Is Required for Lymphocytes to Overcome Their Attraction to Blood

Published:2011-09-30 Issue:6051 Volume:333 Page:1898-1903
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Arnon Tal I.¹,Xu Ying¹,Lo Charles¹,Pham Trung¹,An Jinping¹,Coughlin Shaun²,Dorn Gerald W.³,Cyster Jason G.¹

Affiliation:

1. Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA.

2. Cardiovascular Research Institute, University of California San Francisco, 600 16th Street, San Francisco, CA 94143, USA.

3. Center for Pharmacogenomics, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.

Abstract

A molecular mechanism that allows lymphocytes to migrate against a chemokine gradient is revealed.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference36 articles.

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3. Chemokines in rapid leukocyte adhesion triggering and migration

4. Homing and cellular traffic in lymph nodes

5. Subsecond Induction of α4 Integrin Clustering by Immobilized Chemokines Stimulates Leukocyte Tethering and Rolling on Endothelial Vascular Cell Adhesion Molecule 1 under Flow Conditions

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