Developing a pro-regenerative biomaterial scaffold microenvironment requires T helper 2 cells-Reference-Cited by-同舟云学术

Developing a pro-regenerative biomaterial scaffold microenvironment requires T helper 2 cells

Published:2016-04-15 Issue:6283 Volume:352 Page:366-370
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Sadtler Kaitlyn¹²,Estrellas Kenneth¹²,Allen Brian W.¹²,Wolf Matthew T.¹²,Fan Hongni³²,Tam Ada J.³²,Patel Chirag H.³²,Luber Brandon S.⁴²,Wang Hao⁴²,Wagner Kathryn R.⁵,Powell Jonathan D.³²,Housseau Franck³²,Pardoll Drew M.³²,Elisseeff Jennifer H.¹²

Affiliation:

1. Translational Tissue Engineering Center, Wilmer Eye Institute and Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21287, USA.

2. Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

3. Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.

4. Division of Biostatistics and Bioinformatics, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.

5. Hugo W. Moser Research Institute at Kennedy Krieger Institute, Baltimore, MD 21205, USA, and Departments of Neurology and Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Abstract

Engineering a healing immune response Infections, surgeries, and trauma can all cause major tissue damage. Biomaterial scaffolds, which help to guide regenerating tissue, are an exciting emerging therapeutic strategy to promote tissue repair. Sadtler et al. tested how biomaterial scaffolds interact with the immune system in damaged tissue to promote repair (see the Perspective by Badylak). Scaffolds derived from cardiac muscle and bone extracellular matrix components trigger a tissue-reparative T cell immune response in mice with injured muscles. Science , this issue p. 366 ; see also p. 298

Funder

Maryland Stem Cell Research Fund (MSCRF)

Armed Forces Institute for Regenerative Medicine

U.S. Department of Defense

Research to Prevent Blindness Foundation

Hartwell Foundation

Cancer Center Core

National Institutes of Health

Bloomberg-Kimmel Institute for Cancer Immunotherapy

Publisher

American Association for the Advancement of Science (AAAS)

Subject