Dlk1 Promotes a Fast Motor Neuron Biophysical Signature Required for Peak Force Execution-Reference-Cited by-同舟云学术

Dlk1 Promotes a Fast Motor Neuron Biophysical Signature Required for Peak Force Execution

Published:2014-03-14 Issue:6176 Volume:343 Page:1264-1266
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Müller Daniel¹,Cherukuri Pitchaiah¹,Henningfeld Kristine²³,Poh Chor Hoon¹,Wittler Lars⁴,Grote Phillip⁴,Schlüter Oliver⁵,Schmidt Jennifer⁶,Laborda Jorge⁷,Bauer Steven R.⁸,Brownstone Robert M.⁹,Marquardt Till¹³

Affiliation:

1. Developmental Neurobiology Laboratory, European Neuroscience Institute (ENI-G), Grisebachstraße 5, 37077 Göttingen, Germany.

2. Institute of Developmental Biochemistry, University Medical Center Göttingen, Justus-von-Liebig-Weg 11, 37077 Göttingen, Germany.

3. Center for Nanoscale Microscopy and Molecular Physiology of the Brain, Göttingen, Germany.

4. Department of Developmental Genetics, Max-Planck Institute for Molecular Genetics, Ihnestraße 63-73, 14195 Berlin, Germany.

5. Molecular Neurobiology Laboratory, ENI-G, Grisebachstraße 5, 37077 Göttingen, Germany.

6. Department of Biological Sciences, University of Illinois at Chicago, 900 South Ashland Avenue, MBRB 4210 Chicago, IL 60607, USA.

7. Departament of Inorganic and Organic Chemistry and Biochemistry, University of Castilla–La Mancha Medical School, 02006 C/Almansa 14, Albacete, Spain.

8. Cellular and Tissue Therapies Branch, Division of Cellular and Gene Therapies, Center for Biologics and Research, U.S. Food and Drug Administration, Bethesda, MD 20892, USA.

9. Medical Staff, QEII Health Sciences Centre, Departments of Surgery and Medical Neuroscience, Dalhousie University, Halifax B3H 4R2, Canada.

Abstract

Quick, Quick, Slow The slow muscles of postural stability and the fast muscles of running and jumping are driven by motor neurons that are differentiated by fast and slow biophysical properties. By retrograde labeling of mouse and chick muscle fibers, Müller et al. (p. 1264 ) characterized the developmental distinctions between fast and slow motor neurons. A transmembrane protein, when over- or underexpressed, was discovered to drive specification of the motor neurons and a downstream effector specified some, but not all, of the biophysical attributes.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference43 articles.

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