Total Synthesis of Ciguatoxin CTX3C-Reference-Cited by-同舟云学术

Total Synthesis of Ciguatoxin CTX3C

Published:2001-11-30 Issue:5548 Volume:294 Page:1904-1907
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Hirama Masahiro¹,Oishi Tohru¹,Uehara Hisatoshi¹,Inoue Masayuki¹,Maruyama Megumi¹,Oguri Hiroki¹,Satake Masayuki²

Affiliation:

1. Department of Chemistry, Graduate School of Science, Tohoku University, and CREST, Japan Science and Technology Corporation (JST), Sendai 980-8578, Japan.

2. Department of Applied Bioorganic Chemistry, Graduate School of Life Sciences, Tohoku University, Sendai 980-8555, Japan.

Abstract

More than 20,000 people suffer annually from ciguatera seafood poisoning in subtropical and tropical regions. The extremely low content of the causative neurotoxins, designated as ciguatoxins, in fish has hampered the isolation, detailed biological studies, and preparation of anti-ciguatoxin antibodies for detecting these toxins. The large (3 nanometers long) and complicated molecular structure of ciguatoxins has impeded chemists from completing their total synthesis. Our highly convergent strategic approach featuring the chemoselective ring-closing metathesis reaction as a key tactic has enabled the total synthesis of ciguatoxin CTX3C, which will provide a practical supply for further studies.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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