Affiliation:
1. Max-Planck Institut für Entwicklungsbiologie, Abteilung Zellbiologie, Spemannstrasse 35, 72076 Tübingen, Germany.
Abstract
The fate of ventral epidermal cells differs among nematode species. Nonvulval cells fuse with the epidermis in
Caenorhabditis elegans
, whereas the homologous cells undergo apoptosis in
Pristionchus pacificus
. The homeotic gene
lin-39
is involved in the regulation of these epidermal cell fates. In
Caenorhabditis
,
lin-39
prevents cell fusion of potential vulval cells and specifies the vulva equivalence group.
Pristionchus
vulvaless mutants that displayed apoptosis of the vulval precursor cells were isolated, and point mutations in
lin-39
were identified. Thus, the evolution of these epidermal cell fates is driven by different intrinsic properties of homologous cells.
Publisher
American Association for the Advancement of Science (AAAS)
Reference20 articles.
1. Post-embryonic cell lineages of the nematode, Caenorhabditis elegans
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4. ; Bioessays 19 225 (1997).
5. We would argue that the fusion of nonvulval cells that is seen in Caenorhabditis is ancestral as this cell fate is observed in species of many different families. In particular Strongyloides ratti a species of the order Strongylida that can be considered as an outgroup for both Caenorhabditis and Pristionchus [V. V. Malakhov Nematodes (Smithsonian Institution Press Washington DC 1994)] displays fusion of nonvulval epidermal cells (R. J. Sommer unpublished observation).
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