Comprehensive Mapping of Long-Range Interactions Reveals Folding Principles of the Human Genome-Reference-Cited by-同舟云学术

Comprehensive Mapping of Long-Range Interactions Reveals Folding Principles of the Human Genome

Published:2009-10-09 Issue:5950 Volume:326 Page:289-293
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Lieberman-Aiden Erez¹²³⁴,van Berkum Nynke L.⁵,Williams Louise¹,Imakaev Maxim²,Ragoczy Tobias⁶⁷,Telling Agnes⁶⁷,Amit Ido¹,Lajoie Bryan R.⁵,Sabo Peter J.⁸,Dorschner Michael O.⁸,Sandstrom Richard⁸,Bernstein Bradley¹⁹,Bender M. A.¹⁰,Groudine Mark⁶⁷,Gnirke Andreas¹,Stamatoyannopoulos John⁸,Mirny Leonid A.²¹¹,Lander Eric S.¹¹²¹³,Dekker Job⁵

Affiliation:

1. Broad Institute of Harvard and Massachusetts Institute of Technology (MIT), MA 02139, USA.

2. Division of Health Sciences and Technology, MIT, Cambridge, MA 02139, USA.

3. Program for Evolutionary Dynamics, Department of Organismic and Evolutionary Biology, Department of Mathematics, Harvard University, Cambridge, MA 02138, USA.

4. Department of Applied Mathematics, Harvard University, Cambridge, MA 02138, USA.

5. Program in Gene Function and Expression and Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA.

6. Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

7. Department of Radiation Oncology, University of Washington School of Medicine, Seattle, WA 98195, USA.

8. Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA.

9. Department of Pathology, Harvard Medical School, Boston, MA 02115, USA.

10. Department of Pediatrics, University of Washington, Seattle, WA 98195, USA.

11. Department of Physics, MIT, Cambridge, MA 02139, USA.

12. Department of Biology, MIT, Cambridge, MA 02139, USA.

13. Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA.

Abstract

Chromosomal Mapping The conformation of the genome in the nucleus and contacts between both proximal and distal loci influence gene expression. In order to map genomic contacts, Lieberman-Aiden et al. (p. 289 , see the cover) developed a technique to allow the detection of all interactions between genomic loci in the eukaryotic nucleus followed by deep sequencing. This technology was used to map the organization of the human genome and to examine the spatial proximity of chromosomal loci at one megabase resolution. The map suggests that the genome is partitioned into two spatial compartments that are related to local chromatin state and whose remodeling correlates with changes in the chromatin state.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference36 articles.

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