Structure of nucleosome-bound human BAF complex-Reference-Cited by-同舟云学术

Structure of nucleosome-bound human BAF complex

Published:2020-02-21 Issue:6480 Volume:367 Page:875-881
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

He Shuang¹²^ORCID,Wu Zihan¹²,Tian Yuan¹²^ORCID,Yu Zishuo¹²,Yu Jiali¹²^ORCID,Wang Xinxin¹²,Li Jie¹,Liu Bijun¹^ORCID,Xu Yanhui¹²³⁴^ORCID

Affiliation:

1. Fudan University Shanghai Cancer Center, Institutes of Biomedical Sciences, State Key Laboratory of Genetic Engineering, and Shanghai Key Laboratory of Medical Epigenetics, Shanghai Medical College of Fudan University, Shanghai 200032, China.

2. The International Co-laboratory of Medical Epigenetics and Metabolism, Ministry of Science and Technology, China, Department of Systems Biology for Medicine, School of Basic Medical Sciences, Shanghai Medical College of Fudan University, Shanghai 200032, China.

3. Human Phenome Institute, Collaborative Innovation Center of Genetics and Development, School of Life Sciences, Fudan University, Shanghai 200433, China.

4. CAS Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai 200031, China.

Abstract

Architecture of human BAF complex The SWI/SNF family chromatin remodelers regulate chromatin and transcription. The protein complexes BAF and PBAF are mammalian SWI/SNF remodelers that play essential functions in diverse developmental and physiological processes. He et al. determined the structure of the human BAF complex, which contains three modules that bind the nucleosome on the top, bottom, and side, making this nucleosome-recognition pattern distinct from other chromatin remodelers. Mutations in BAF that are frequently associated with human cancer cluster into a nucleosome-interacting region. This structure provides a framework for understanding the BAF-mediated chromatin remodeling mechanism and its dysregulation in cancer. Science , this issue p. 875

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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