The Genetic Program of Hematopoietic Stem Cells-Reference-Cited by-同舟云学术

The Genetic Program of Hematopoietic Stem Cells

Published:2000-06-02 Issue:5471 Volume:288 Page:1635-1640
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Phillips Robert L.¹,Ernst Robin E.¹,Brunk Brian²,Ivanova Natalia¹,Mahan Mark A.¹,Deanehan Julia K.¹,Moore Kateri A.¹,Overton G. Christian²,Lemischka Ihor R.¹

Affiliation:

1. Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA.

2. Computational Biology and Informatics Laboratory, University of Pennsylvania, Philadelphia, PA 19104, USA.

Abstract

Blood cell production originates from a rare population of multipotent, self-renewing stem cells. A genome-wide gene expression analysis was performed in order to define regulatory pathways in stem cells as well as their global genetic program. Subtracted complementary DNA libraries from highly purified murine fetal liver stem cells were analyzed with bioinformatic and array hybridization strategies. A large percentage of the several thousand gene products that have been characterized correspond to previously undescribed molecules with properties suggestive of regulatory functions. The complete data, available in a biological process–oriented database, represent the molecular phenotype of the hematopoietic stem cell.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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