Bacteriophage trigger antiviral immunity and prevent clearance of bacterial infection-Reference-Cited by-同舟云学术

Bacteriophage trigger antiviral immunity and prevent clearance of bacterial infection

Published:2019-03-29 Issue:6434 Volume:363 Page:
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Sweere Johanna M.¹²^ORCID,Van Belleghem Jonas D.¹^ORCID,Ishak Heather¹³^ORCID,Bach Michelle S.¹^ORCID,Popescu Medeea¹²^ORCID,Sunkari Vivekananda¹,Kaber Gernot¹,Manasherob Robert¹,Suh Gina A.¹^ORCID,Cao Xiou¹^ORCID,de Vries Christiaan R.¹^ORCID,Lam Dung N.¹,Marshall Payton L.¹²^ORCID,Birukova Maria¹²,Katznelson Ethan¹,Lazzareschi Daniel V.¹,Balaji Swathi⁴^ORCID,Keswani Sundeep G.⁴^ORCID,Hawn Thomas R.⁵^ORCID,Secor Patrick R.⁶^ORCID,Bollyky Paul L.¹^ORCID

Affiliation:

1. Division of Infectious Diseases and Geographic Medicine, Department of Medicine, Stanford University, Stanford, CA, USA.

2. Stanford Immunology, Stanford University, Stanford, CA, USA.

3. Palo Alto Veterans Institute of Research, Palo Alto, CA, USA.

4. Division of Pediatric Surgery, Department of Surgery, Baylor College of Medicine, Houston, TX, USA.

5. Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, WA, USA.

6. Division of Biological Sciences, University of Montana, Missoula, MT, USA.

Abstract

Phage subverts immune response Pseudomonas aeruginosa ( Pa ) is a multidrug-resistant Gramnegative bacterium commonly found in health care settings. Pa infections frequently result in considerable morbidity and mortality. Sweere et al. found that a type of temperate filamentous bacteriophage that infects and integrates into Pa is associated with chronic human wound infections. Likewise, wounds in mice colonized with phage-infected Pa were more severe and longer-lasting than those colonized by Pa alone. Immune cell uptake of phage-infected Pa resulted in phage RNA production and inappropriate antiviral immune responses, impeding bacterial clearance. Both phage vaccination and transfer of antiphage antibodies were protective against Pa infection. Science , this issue p. eaat9691

Funder

National Institute of Allergy and Infectious Diseases

Cystic Fibrosis Foundation

Dr. Ralph and Marian Falk Medical Research Trust

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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