Epigenomic Enhancer Profiling Defines a Signature of Colon Cancer-Reference-Cited by-同舟云学术

Epigenomic Enhancer Profiling Defines a Signature of Colon Cancer

Published:2012-05-11 Issue:6082 Volume:336 Page:736-739
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Akhtar-Zaidi Batool¹²,Cowper-Sal·lari Richard³,Corradin Olivia¹,Saiakhova Alina¹,Bartels Cynthia F.¹,Balasubramanian Dheepa¹,Myeroff Lois⁴,Lutterbaugh James⁴,Jarrar Awad⁵,Kalady Matthew F.⁴⁵⁶,Willis Joseph⁴⁷,Moore Jason H.³,Tesar Paul J.¹⁴,Laframboise Thomas¹⁴,Markowitz Sanford¹⁴⁸,Lupien Mathieu³⁹,Scacheri Peter C.¹²⁴

Affiliation:

1. Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH 44106, USA.

2. Department of Molecular Medicine of the Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.

3. Norris Cotton Cancer Center, Institute for Quantitative Biomedical Sciences, Department of Genetics, Dartmouth Medical School, Lebanon, NH 03756, USA.

4. Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106, USA.

5. Department of Colorectal Surgery, Cleveland Clinic Foundation, Cleveland, OH 44195, USA.

6. Cancer Biology Department, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA.

7. Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA.

8. Department of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.

9. Ontario Cancer Institute, University Health Network and Department of Medical Biophysics, University of Toronto, Toronto, Ontario, M5G 1L7, USA.

Abstract

Colorectal Cancer Signature The mutations and genome aberrations that characterize cancer result in often dramatically altered gene and protein expression patterns. It is these altered expression patterns that directly and indirectly drive progression of the disease. In human primary colorectal cancer cells, Akhtar-Zaidi et al. (p. 736 , published online 12 April) analyzed the pattern of epigenetically modified chromatin at “enhancer” sequences that are known to be critical in the control of gene expression. An epigenetic enhancer signature was defined that was specifically associated with colorectal cancer cells.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference22 articles.

1. Histone modifications at human enhancers reflect global cell-type-specific gene expression

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