Characterization of a common progenitor pool of the epicardium and myocardium-Reference-Cited by-同舟云学术

Characterization of a common progenitor pool of the epicardium and myocardium

Published:2021-03-05 Issue:6533 Volume:371 Page:
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Tyser Richard C. V.¹^ORCID,Ibarra-Soria Ximena²^ORCID,McDole Katie³,Arcot Jayaram Satish¹,Godwin Jonathan¹^ORCID,van den Brand Teun A. H.⁴^ORCID,Miranda Antonio M. A.¹,Scialdone Antonio⁵⁶⁷^ORCID,Keller Philipp J.³^ORCID,Marioni John C.²⁴⁸^ORCID,Srinivas Shankar¹^ORCID

Affiliation:

1. Department of Physiology, Anatomy and Genetics, South Parks Road, University of Oxford, Oxford OX1 3QX, UK.

2. Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK.

3. Howard Hughes Medical Institute, Janelia Research Campus, 19700 Helix Drive, Ashburn, VA 20147, USA.

4. European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Cambridge CB10 1SD, UK.

5. Institute of Epigenetics and Stem Cells, Helmholtz Zentrum München, D-81377 München, Germany.

6. Institute of Functional Epigenetics, Helmholtz Zentrum München, D-85764 Neuherberg, Germany.

7. Institute of Computational Biology, Helmholtz Zentrum München, D-85764 Neuherberg, Germany.

8. Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge CB10 1SA, UK.

Abstract

Forming the early heart The heart is the first organ to form during development and is critical for the survival of the embryo. The precise molecular identities of the various cell types that make up the heart during these early stages remain poorly defined. Tyser et al. used a combination of transcriptomic, imaging, and genetic lineage–labeling approaches to profile the molecular identity and precise locations of cells involved in the formation of the mouse embryonic heart. This approach allowed them to identify the earliest known progenitor of the epicardium, the outermost layer of the heart, which is an important source of signals and cells during cardiac development and injury. Science , this issue p. eabb2986

Funder

Howard Hughes Medical Institute

Wellcome

British Heart Foundation

Cancer Research UK

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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