Ordered and Dynamic Assembly of Single Spliceosomes-Reference-Cited by-同舟云学术

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Ordered and Dynamic Assembly of Single Spliceosomes

Published:2011-03-11 Issue:6022 Volume:331 Page:1289-1295
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Hoskins Aaron A.¹²,Friedman Larry J.²,Gallagher Sarah S.³,Crawford Daniel J.¹²,Anderson Eric G.¹,Wombacher Richard³,Ramirez Nicholas¹,Cornish Virginia W.³,Gelles Jeff²,Moore Melissa J.¹

Affiliation:

1. Department of Biochemistry and Molecular Pharmacology, Howard Hughes Medical Institute, University of Massachusetts Medical School, Worcester, MA 01605, USA.

2. Department of Biochemistry, Brandeis University, Waltham, MA 02454, USA.

3. Department of Chemistry, Columbia University, New York, NY 10027, USA.

Abstract

Fluorescently labeled yeast spliceosome proteins reveal the events of intron splicing as it happens.

Funder

National Institutes of Health

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Link

http://www.sciencemag.org/content/331/6022/1289.full.pdf

Reference23 articles.

1. The spliceosome: the most complex macromolecular machine in the cell?

2. The Evolutionarily Conserved Core Design of the Catalytic Activation Step of the Yeast Spliceosome

3. The Spliceosome: Design Principles of a Dynamic RNP Machine

4. Composition and Functional Characterization of the Yeast Spliceosomal Penta-snRNP

5. Prp5 bridges U1 and U2 snRNPs and enables stable U2 snRNP association with intron RNA

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