A nontoxic pain killer designed by modeling of pathological receptor conformations-Reference-Cited by-同舟云学术

A nontoxic pain killer designed by modeling of pathological receptor conformations

Published:2017-03-03 Issue:6328 Volume:355 Page:966-969
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Spahn V.¹^ORCID,Del Vecchio G.¹^ORCID,Labuz D.¹^ORCID,Rodriguez-Gaztelumendi A.¹^ORCID,Massaly N.¹^ORCID,Temp J.¹^ORCID,Durmaz V.²^ORCID,Sabri P.²,Reidelbach M.²^ORCID,Machelska H.¹^ORCID,Weber M.²^ORCID,Stein C.¹^ORCID

Affiliation:

1. Department of Anesthesiology and Critical Care Medicine, Charité-Universitätsmedizin Berlin Campus Benjamin Franklin, Freie Universität Berlin, Hindenburgdamm 30, Berlin 12203, Germany.

2. Computational Molecular Design, Zuse-Institut Berlin, Takustrasse 7, Berlin, 14195, Germany.

Abstract

A pain killer without side effects Opioids are very strong and effective pain killers. However, they also have a range of well-known side effects and can cause addiction. Painful conditions such as inflammation or trauma are often associated with localized tissue acidification. Spahn et al. designed a novel opioid receptor agonist that, unlike clinically used opioids, best activates the receptors in such acidified tissues. In rat models of inflammatory pain, the new drug exerted strong pain relief essentially without the side effects of standard opioids. Science , this issue p. 966

Funder

Bundesministerium für Bildung und Forschung

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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