Viruses transfer the antiviral second messenger cGAMP between cells-Reference-Cited by-同舟云学术

Viruses transfer the antiviral second messenger cGAMP between cells

Published:2015-09-11 Issue:6253 Volume:349 Page:1228-1232
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Bridgeman A.¹,Maelfait J.¹,Davenne T.¹,Partridge T.²,Peng Y.¹,Mayer A.¹,Dong T.¹,Kaever V.³,Borrow P.²,Rehwinkel J.¹

Affiliation:

1. Medical Research Council Human Immunology Unit, Medical Research Council Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DS, UK.

2. Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, UK.

3. Research Core Unit Metabolomics, Institute of Pharmacology, Hannover Medical School, Carl-Neuberg-Strasse 1, D-30625 Hannover, Germany.

Abstract

Viruses pack antiviral mediators Viruses often hijack host proteins for their own use, turning host cells into virion-spewing machines. However, Bridgeman et al. and Gentili et al. now report a sneaky way that the host can fight back (see the Perspective by Schoggins). Host cells that expressed the enzyme cGAS, an innate immune receptor that senses cytoplasmic DNA, packaged the cGAS-generated second messenger cGAMP into virions. Virions could then transfer cGAMP to neighboring cells, triggering an antiviral gene program in these newly infected cells. Such transfer of an antiviral mediator may help to speed up the immune response to put the brakes on viral spread. Science , this issue pp. 1228 and 1232 ; see also p. 1166

Funder

NIH

National Institute of Allergy and Infectious Diseases

European Molecular Biology Organization

Wellcome Trust

UK Medical Research Council

MRC Human Immunology Unit

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference36 articles.