The Ro60 autoantigen binds endogenous retroelements and regulates inflammatory gene expression-Reference-Cited by-同舟云学术

The Ro60 autoantigen binds endogenous retroelements and regulates inflammatory gene expression

Published:2015-10-23 Issue:6259 Volume:350 Page:455-459
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Hung T.¹,Pratt G. A.²,Sundararaman B.²,Townsend M. J.¹,Chaivorapol C.¹,Bhangale T.¹,Graham R. R.¹,Ortmann W.¹,Criswell L. A.³,Yeo G. W.²⁴⁵,Behrens T. W.¹

Affiliation:

1. Genentech, South San Francisco, CA 94080, USA.

2. Department of Cellular and Molecular Medicine, Institute for Genomic Medicine, Stem Cell Program, University of California at San Diego, Sanford Consortium for Regenerative Medicine, 2880 Torrey Pines Scenic Drive, La Jolla, CA 92037, USA.

3. Rosalind Russell/Ephraim P. Engleman Rheumatology Research Center, University of California, San Francisco, CA 94143, USA.

4. Department of Physiology, National University of Singapore, Singapore.

5. Genome Institute of Singapore and Molecular Engineering Laboratory, Agency for Science, Technology and Research, Singapore.

Abstract

An Aluring new autoantibody target Autoimmunity is the immune system's ultimate act of betrayal. Cells designed to protect against invading microbes suddenly target the host instead. In the autoimmune disease systemic lupus erythematosus, antibodies target DNA and host proteins, including the RNA binding protein Ro60. Hung et al. discovered that Ro60 bound to endogenous Alu retroelements. They detected antibody-Ro60-Alu RNA immune complexes in the blood of individuals with lupus and an enrichment of Alu transcripts. Ro60 bound to Alu probably primes RNA-binding innate immune receptors within B cells, leading these cells to make antibodies that target Ro60-Alu RNA and drive disease-causing inflammation. Science , this issue p. 455

Funder

NSF

NIH

Alfred P. Sloan research

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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