RNA Polymerase IV Directs Silencing of Endogenous DNA

Author:

Herr A. J.12,Jensen M. B.12,Dalmay T.12,Baulcombe D. C.12

Affiliation:

1. Sainsbury Laboratory, John Innes Centre, Norwich NR4 7UH, UK.

2. University of East Anglia, Norwich NR4 7TJ, UK.

Abstract

Plants encode subunits for a fourth RNA polymerase (Pol IV) in addition to the well-known DNA-dependent RNA polymerases I, II, and III. By mutation of the two largest subunits (NRPD1a and NRPD2), we show that Pol IV silences certain transposons and repetitive DNA in a short interfering RNA pathway involving RNA-dependent RNA polymerase 2 and Dicer-like 3. The existence of this distinct silencing polymerase may explain the paradoxical involvement of an RNA silencing pathway in maintenance of transcriptional silencing.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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